Translated from german language with Google Translation:
Studies have shown that omega-3s are beneficial to health in many ways. Especially appreciated is the positive effect on the inflammatory regulation. It is believed that the effect of the long-chain, polyunsaturated omega-3 fatty acids is mediated by oxidative metabolites. These include so-called eicosanoids or oxylipins. In an intervention study, scientists from the University of Wuppertal investigated the influence of marine omega-3 fatty acids on the plasma levels of oxylipins. 121 healthy adults with initially low fish consumption received supplements with the marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) or a placebo for 12 months. The dosage of omega-3 fatty acids was chosen to be either one, two or four servings of fish per week.
A total of 73 oxylipins were identified in the plasma of participants at 3 and 12 months. The oxylipin concentration increased linearly depending on omega-3 fatty acid intake. This effect was observable at 3 and 12 months for all EPA and DHA oxylipin metabolites.
The oxylipin level seems to be directly related to the intake of marine omega-3 fatty acids and may explain the positive effect on the inflammatory reactions.
Ostermann AI, West AL, Schoenfeld K, Browning LM, Walker CG, Jebb SA, Calder PC, Schebb NH.
Plasma oxylipins respond in a linear dose-response manner with increased intake of EPA and DHA: results from a randomized controlled trial in healthy humans.
At the J Clin Nutr. 5/2019; 109 (5): 1251-63.